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Ultrasound-enhanced drug dispersion through solid tumours and itspossible role in aiding ultrasound-targeted cancer chemotherapy

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Nomikou, Nikolitsa, Li, Ying Suet and McHale, Anthony (2010) Ultrasound-enhanced drug dispersion through solid tumours and itspossible role in aiding ultrasound-targeted cancer chemotherapy. Cancer Letters, 288 . pp. 94-98. [Journal article]

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DOI: 10.1016/j.canlet.2009.06.028

Abstract

It has been demonstrated that inadequate dispersion of cancer chemotherapeutic drugsthroughout the tissues of larger, relatively poorly vascularised tumours compromises thetherapeutic effectiveness of such drugs. Recently we demonstrated that electric fields couldbe exploited to achieve dispersion of a cancer chemotherapeutic drug through relativelyimpermeable tissues of a poorly vascularised solid tumour model. Using a modified SonidelSP100 sonoporator we demonstrate that ultrasound may enhance the toxicity of a cancerchemotherapeutic drug by dispersing the drug through relatively impermeable tissues of anon-vascularised tumour model in vivo. We suggest that such a phenomenon may play asignificant role in ultrasound targeting of cancer chemotherapeutic drugs, particularly inthe treatment of solid tumours.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Pharmacy and Pharmaceutical Science
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:11130
Deposited By:Professor Anthony McHale
Deposited On:04 Feb 2010 09:38
Last Modified:29 Nov 2012 12:30

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