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Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Smyth, Franklin (2003) Electrospray ionisation mass spectrometric behaviour of selected drugs and their metabolites. ANALYTICA CHIMICA ACTA, 492 (1-2). pp. 1-16. [Journal article]

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Abstract

A review of recent applications of HPLC-electrospray ionisation mass spectrometry (ESI-MS) to the analysis of selected drugs and their metabolites is presented. The drugs are chosen according to selected structural classes in which the molecules give ESI signals as [M+1](+), [M-1](-), [M+Na](+) ions. Details are given on the fragmentations that these ionic species exhibit in-source, in ion-traps and in triple quadrupoles. The review is principally concerned with the electrospray ionisation mass spectrometric behaviour of these drugs and their metabolites but details are given of corresponding SPE and HPLC procedures. (C)2002 Elsevier Science B.V. All rights reserved.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:1092
Deposited By:Prof W.Franklin Smyth
Deposited On:11 Jan 2010 16:32
Last Modified:04 May 2012 09:19

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