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Electrospray ionisation-mass spectrometry (ESI-MS) and liquid chromatography-electrospray ionisation-mass spectrometry (LC-ESI-MS) of selected pharmaceuticals

Biomedical Sciences Research Institute Computer Science Research Institute Environmental Sciences Research Institute Nanotechnology & Advanced Materials Research Institute

Smyth, Franklin (2006) Electrospray ionisation-mass spectrometry (ESI-MS) and liquid chromatography-electrospray ionisation-mass spectrometry (LC-ESI-MS) of selected pharmaceuticals. CURRENT PHARMACEUTICAL ANALYSIS, 2 (3). pp. 299-311. [Journal article]

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Abstract

This review surveys recent publications on the Electrospray Ionisation - Mass Spectrometry (ESI-MS) of drugs of small molecular mass taken from selected drug classes using the Web of Knowledge database. The structural classes are antibiotics/antibacterials, steroids, cannabinols, antidiabetics, immunosuppressants, antitumour drugs, antiretroviral drugs, nonsteroidal antiinflammatories, mucolytic drugs, anticoagulants, cyclooxygenase inhibitors, stimulants, noradrenergic agents, anti-TB drugs and erectile dysfunction agents. Fragmentation information that these drugs exhibit in-source and in ion-trap, triple quadrupole and time-of flight mass spectrometers is also provided. An appraisal of applications for the period 2004-2005, again taken from the Web of Knowledge database, of the technique liquid chromatography - electrospray ionization - mass spectrometry (LC-ESI-MS)to the detection and determination of these drugs, primarily in biomatrices, is then made. Information on such aspects as sample concentration, LC separation conditions, recoveries from biological media and limits of detection (LODs) are provided.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Biomedical Sciences
Research Institutes and Groups:Biomedical Sciences Research Institute
Biomedical Sciences Research Institute > Pharmaceutical Science and Practice
ID Code:1080
Deposited By:Prof W.Franklin Smyth
Deposited On:11 Jan 2010 16:42
Last Modified:04 May 2012 09:19

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