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Childhood sexual abuse, early cannabis use, and psychosis: Testing an interaction model based on the national comorbidity survey

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Houston, JE, Murphy, Jamie, Adamson, Gary, Stringer, Maurice and Shevlin, Mark (2008) Childhood sexual abuse, early cannabis use, and psychosis: Testing an interaction model based on the national comorbidity survey. SCHIZOPHRENIA BULLETIN, 34 (3). pp. 580-585. [Journal article]

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DOI: 10.1093/schbul/sbm127


Previous research investigating the etiology of psychosis has identified risk factors such as childhood sexual abuse and cannabis use. This study investigated the multiplicative effect of these variables on clinically assessed diagnoses of psychosis based on a large community sample (the National Comorbidity Survey). Demographic variables (sex, age, urbanicity, ethnicity, education, employment, and living arrangements) and depression were used as predictors in the first block of a binary logistic regression. In the second block, the variables representing early cannabis use, childhood sexual trauma, and the interaction between these variables were entered. There was no significant main effect for early cannabis use or childhood sexual trauma. The interaction was statistically significant (odds ratio [OR] = 6.93, 95% confidence interval [CI] = 1.39-34.63, P = .02). The effect for the sexual trauma variable was statistically significant for those who used cannabis under 16 years (OR = 11.96, 95% CI = 2.10-68.22, P = .01) but not for those who had not used cannabis under 16 years (OR = 1.80, 95% CI = 0.91-3.57, P = .09). Many factors have been shown to be significant in the etiology of psychosis; however, the current research augments previous findings by examining psychosis in terms of an interaction between 2 of these factors.

Item Type:Journal article
Faculties and Schools:Faculty of Life and Health Sciences
Faculty of Life and Health Sciences > School of Psychology
Research Institutes and Groups:Psychology Research Institute
Psychology Research Institute > Psychological Epidemiology and Mental Health
Psychology Research Institute > Peace, Conflict & Equality
ID Code:1004
Deposited By:Mrs Fiona Harkin
Deposited On:07 Dec 2009 16:13
Last Modified:29 May 2013 13:18

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